Aggressive hubs tend to locate on the system modules
The better clustering coefficients seen to possess aggressive hubs may suggest that competitive sides are more inclined to function groups regarding human CCRN. Of the merely considering aggressive sides for aggressive hubs and you may cooperative edges to possess cooperative hubs, i re also-determined the clustering coefficients and you can opposed the distributions from clustering coefficients between competitive hubs and you may collaborative hubs. We discover you to definitely aggressive hubs need far more significantly high clustering coefficients than cooperative hubs (one-tailed Wilcoxon’s attempt, p-worth = 4.8 ? 10 ?57 ; Secondary Fig. S2). This result verifies one competitive hubs tend to to acquire into the a beneficial party out of necessary protein heavily connected by aggressive edges, or rather, competitive sides will aggregate throughout the human CCRN.
To advance verify so it, i did that even more analysis
The noticeable divergence involving the fungus and you will people CCRNs spurs our very own next analysis. We find you to particular protein domain names simply can be found in the human CCRN, with regards to the Pfam domain annotations sixteen . We introduced such domains as people-particular domain names and you may defined the protein that contains the human-certain domains just like the person-specific necessary protein (a full selection of individual-certain proteins exists at all other protein on the human CCRN have been defined as the human being non-certain proteins. Ver mas
